In addition to Psilocybe species, there are several different kinds of magic mushrooms. Many of these also produce psilocybin, including certain mushrooms from the following genera: Even within these four species, there’s a tremendous amount of variance. There are literally hundreds of mushrooms how do psilocybin mushrooms work with psychotropic properties, which is why working with a professional is always a good idea. If you’re looking to explore yourself, especially with a therapeutic purpose, psilocybin mushrooms can be a tool for working through trauma and developing a strong sense of self. It could be the help you need to make sense of the only taxonomic category over which you have any control: yourself. Watch "A trip through the garden: Episode 2 Magic Mushrooms" A large portion of these 5HT2A receptors are located in cells in the cortex; an area of the brain associated with reasoning and rational thought. These cells are also quite long — they span an area of the brain larger than many other cells and therefore have a wider influence over brain activity.